RESUMO
A 42-year-old man had extensive occlusive disease of the coronary artery and angina pectoris. An autogenous saphenous vein bypass from the ascending aorta to the anterior descending coronary artery was performed on Nov 23, 1964. The patient suffered an asymptomatic anterior myocardial infarction during operation but made an uncomplicated recovery. Seven years after the operation, the graft functions with normal left ventricular hemodynamics, while the occlusive process has produced obstruction of the left main coronary artery and almost complete occlusion of the right coronary artery. To our knowledge, this is the first successful case of a saphenous vein-coronary artery bypass with the longest follow-up of a functioning coronary vein bypass graft.
Assuntos
Ponte de Artéria Coronária/história , Veia Safena/transplante , Grau de Desobstrução Vascular , História do Século XX , Humanos , MasculinoAssuntos
Hicantone/farmacologia , Esquistossomicidas , Tioxantenos/farmacologia , Animais , Gatos , Cricetinae , Cães , Tolerância a Medicamentos , Feminino , Haplorrinos , Humanos , Hicantone/metabolismo , Hicantone/uso terapêutico , Hicantone/toxicidade , Masculino , Camundongos , Gravidez , Coelhos , Ratos , Schistosoma mansoni , Esquistossomose/tratamento farmacológico , CaramujosAssuntos
Etilenodiaminas/uso terapêutico , Hicantone/administração & dosagem , Esquistossomose/tratamento farmacológico , Esquistossomicidas/uso terapêutico , Tioxantenos/administração & dosagem , Tioxantenos/uso terapêutico , Administração Oral , Adolescente , Adulto , África , Animais , Pressão Sanguínea/efeitos dos fármacos , Temperatura Corporal/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Brasil , Gatos , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Criança , Pré-Escolar , Avaliação de Medicamentos , Eletrocardiografia , Eletroencefalografia , Etilenodiaminas/administração & dosagem , Etilenodiaminas/efeitos adversos , Etilenodiaminas/toxicidade , Feminino , Humanos , Hicantone/efeitos adversos , Lactente , Injeções Intramusculares , Fígado/efeitos dos fármacos , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Schistosoma/efeitos dos fármacos , Schistosoma haematobium , Schistosoma mansoni , Esquistossomicidas/administração & dosagem , Esquistossomicidas/efeitos adversos , Esquistossomicidas/toxicidade , Tioxantenos/efeitos adversos , Tioxantenos/toxicidadeAssuntos
Ponte de Artéria Coronária , Veia Safena/transplante , Adulto , Angiografia , Aorta/cirurgia , Arteriopatias Oclusivas/complicações , Arteriosclerose , Doença das Coronárias/cirurgia , Eletrocardiografia , Seguimentos , Humanos , Masculino , Técnicas de Sutura , Fatores de Tempo , Transplante AutólogoAssuntos
Circulação Cerebrovascular , Transtornos Cerebrovasculares/diagnóstico , Adulto , Fatores Etários , Idoso , Velocidade do Fluxo Sanguíneo , Angiografia Cerebral , Córtex Cerebral/metabolismo , Transtornos Cerebrovasculares/metabolismo , Eletroencefalografia , Feminino , Glucose/metabolismo , Humanos , Ataque Isquêmico Transitório/metabolismo , Lactatos/metabolismo , Masculino , Pessoa de Meia-Idade , Consumo de Oxigênio , Prognóstico , Piruvatos/metabolismoRESUMO
The absorption, distribution, and excretion of hycanthone were studied with rats and rhesus monkeys using tritiated materials at the therapeutic dose recommended for man (3.0+/-0.5 mg/kg). Nine pairs of each species received single intramuscular doses of randomly tritiated (specific activity 193.7 mCi/mmol) hycanthone methanesulfonate and were then sacrificed at intervals between 15 min and 72 h after medication. Peak blood and tissue concentrations occurred 30-60 min after administration (plasma half-life-45 min). The highest concentrations were observed in the liver, spleen, kidneys and adrenals, but decreased rapidly (more than 80% of the dose was excreted in 48-72 hours). In monkeys a high concentration of the compound was found in the bile (hours 1-8), probably conjugated to glucuronic acid.Radiochromatography showed only unchanged drug in the blood and tissues, except in the liver where rapid conversion occurred to sulfoxide in the rat and to the deethyl analogue in the monkey.
Assuntos
Anti-Helmínticos/metabolismo , Haplorrinos/metabolismo , Ratos/metabolismo , Xantenos/metabolismo , Glândulas Suprarrenais/metabolismo , Animais , Anti-Helmínticos/sangue , Bile/metabolismo , Etilaminas/metabolismo , Rim/metabolismo , Fígado/metabolismo , Macaca/metabolismo , Masculino , Metanol/metabolismo , Ratos Endogâmicos/metabolismo , Especificidade da Espécie , Baço/metabolismo , TrítioRESUMO
Mice infected with Schistosoma mansoni were given an intramuscular injection of a single 80 mg/kg dose of randomly tritiated hycanthone. The uptake of the drug in male and female worms, as well as its concentration in the red blood cells and plasma of the mice, was followed for a period of 24 hours.Blood and plasma drug levels reached maximum values within 30 minutes. During the postmedication period, plasma concentrations were consistently higher than red blood cell concentrations. At 2-6 hours, when blood levels were declining, peak uptake was reached in the female schistosome worms; the concentration in the female worm was 5 times higher than in the male worm. At 24 hours the schistosomes contained appreciably more drug than was present in the blood.
